Alzet surgical implantation procedures video youtube. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic pumps. Durect corporation alzet osmotic no 1004 pump alzet. Alzet pumps have been used to target delivery to a wide variety of sites including the spinal cord, spleen, liver, organ or tissue transplants, and wound. Catheter tubing catheters premade needles port plugs tubing connectors stopcocks stylets injection ports osmotic pumps. Prior to inserting the minipumps, mice will be anesthetized using avertin 0. Durect corporation alzet osmotic no 1004 pump alzet osmotic no 1004 pump. This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents. Specify the model, order number and quantity of pumps you require. Ppt electro osmotic pumps powerpoint presentation free.
As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Versatile and highly swellable polyox watersoluble resins help with the production of osmotic pump technologies. Alzet surgical implantation procedures video on vimeo. Osmotic pump delivery systems are typically produced on a bilayer tablet press and subsequently coated with a semipermeable membrane. Osmotic micropumps for drug delivery are applied to a broad range of different applications addressing multiple routes of administration. It is generally used intravenously, although subcutaneous, arterial and epidural infusions are occasionally used infusion pumps can administer fluids in ways that would be impractically expensive or unreliable if performed manually by nursing staff. Lab animals this video shows lab animals implanted with alzet pumps, and describes how alzet pumps improve animal welfare by reducing the stress caused by repetitive injections and frequent animal handling. Subcutaneous angiotensin ii infusion using osmotic pumps. Osmotic pumps are miniature infusion pumps for the continuous dosing of laboratory animals. Individual lots of pumps may vary from this target within limits.
Microosmotic pumps for continuous release of the tyrosine kinase inhibitor bosutinib in juvenile rats and its impact on bone growth. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. Video article demonstrating icv delivery to the mouse cns. This video article jove describes a method for targeted administration of drugs to the central nervous system by either continuous delivery using alzet osmotic pumps or performing bolus injections into the right lateral ventricle of mice. These type of drug delivery systems release the active ingradient at an osmotically controlled rate over a prolonged period of time alza corporation pioneered the development of osmotic drug delivery systems. Highmolecularweight polyox is used to formulate the push layer, whereas the pull layer. This 20 minute video describes the alzet pump mechanism, and the advantages of continuous infusion over frequent. In general, three different operating principles of osmotic pumps having distinct advantages and. Osmotic pumps are one of the systems for controlled drug delivery.
Alzet resource videos osmotic pump mechanism on vimeo. Osmotic drug delivery systems typically consist of a drug core containing osmogen that is coated with a semipermeable membrane. Appendix 11 video tapes vhs available through veterinary resources current 1999 1. Alzet osmotic pumps surgical implantation techniques alza corp. Watch this short video to learn how alzet osmotic pumps work to enable reliable and continuous delivery.
Preparation of alzet osmotic pumps for subcutaneous implantation reagentssupplies 1. This video describes proper filling of the alzet pump and and surgical techniques for implantation in rats and mice including subcutaneous and interperitoneal. Durect manufactures and sells alzet osmotic pumps and accessories on a worldwide basis. Though these solvents exhibit the potential to solubilize several poorly soluble compounds, the solubilized compounds are prone to crystallization up on contact. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic. Implantable infusion pumps insights for your next animal dosing study. Durect corporation 2006 alzet osmotic pump 42 day 2006. Osmotic micropumps for drug delivery sciencedirect. Articular cavity, blood vessels, bone, brain solid tissue, brain ventricles, ear, eye, muscle, nerves, spinal cord, stomach, and tumors.
Whatever i found, it was either alzet or a reseller of alzet. The semipermeable barrier 14 is impermeable for the osmotic active substance and permeable for the solvent 17. Alzet pumps can also be used for targeted delivery, where the effects of a drug or test agent are localized in a particular tissue or organ, by means of a catheter. Durect corporation 2006 alzet osmotic pump 42 day 2006 alzet osmotic pump 42 day. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery alzet resource videos osmotic pump mechanism on vimeo. Selfpowered pumps are then implanted either subcutaneously or intraperitoneally. Alzet osmotic pumps surgical implantation techniques. Isoproterenol 17 mgkgday was administered to mice using alzet osmotic minipumps durect corp, cupertino, ca. Alzet pumps deliver by the process of osmotic displacement. The osmoticcontrolled release oral delivery system oros is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semipermeable outer membrane and one or more small laser drilled holes in it. Continuous delivery ensures constant compound levels in plasma or tissues for. Alzet osmotic pumps have been a part of successful research for more than 40 years. Alzet pumps are miniature delivery systems designed to provide constant, accurate administration of test agents. Alzet osmotic pumps have been a part of successful research for over 40 years.
This video describes proper filling of the alzet pump and and surgical techniques for implantation in rats and mice including subcutaneous and interperitoneal implantation, and the use of a catheter for intravenous, intrathecal, intragastric, and cranialcerebral infusion. Department of pharmaceutics, institute of pharmacy, nirma university, sarkhejgandhinagar highway, ahmadabad 382 481, gujarat, india. Alzet osmotic infusion pumps model 2002 pack of 10 pumps. These minipumps deliver drugs, hormones, and other test agents at continuous and. These minipumps deliver drugs, hormones, and other test agents at continuous and controlled rates, for durations ranging from one day to six weeks, without the need for external connections or frequent handling. These selfpowered pumps offer a convenient and efficient method for longterm dosing of mice and rats. Alzet osmotic pumps are miniature infusion systems that deliver test agents at. Convenient, reliable, and costeffective alternative to chronic injections.
A filling needle is included in the box with osmotic pumps. The historical development of osmotic systems includes development of the rosenelson pump, the higuchileeper pumps, the alzet and osmet systems, the elementary osmotic pump, and the pushpull. Only the magnitude and the duration of delivery change. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the. If you require further information on these osmotic pumps, feel free to contact us at the following. Alzet osmotic pumps implantable infusion pumps for. Video articles in jove about mini osmotic pump include spectral confocal imaging of fluorescently tagged nicotinic receptors in knockin mice with chronic nicotine administration, construction and implantation of a microinfusion system for sustained delivery of neuroactive agents. A grasping tool device for delicately grasping tissue comprising.
These minipumps provide researchers with a method for controlled and continuous agent delivery in vivo. Principles of the design and operation of generic osmotic pumps. Download free osmosis prime videos 2018 875 videos go beyond medical lectures. The automatic operation and small size of alzet pumps make them an ideal infusion system for chronic dosing studies in nude and scid mouse models. Introduction osmosis refers to the process of movement of solvent from lower concentration of solute towards higher concentration of solute across a semi permeable membrane till the equilibrium achieved. This video describes the subcutaneous and intraperitoneal implantation procedures. The nominal performance is a target for all pumps manufactured. Electro osmotic pumps is the property of its rightful owner. By varying the concentration of the active agent in the dispersion, the amounts delivered can be varied at a constant temperature amkraut et al. There are 12 models of alzet osmotic pumps in 3 physical sizes, and a variety of release rates and durations. Alzet osmotic pumps have been used extensively in immunodeficient mice since 1980 and over 300 publications are available as evidence of their research value in these species. Comprehensive coverage of pathology, physiology, pharmacology, and clinical reasoning videos you wont find anywhere else. Free access to all jove education videos until june 15. This coating has one or more delivery ports through which a solution or suspension of the drug is released over time.
Download article pdf download research materials list. You may wish to print this form before submitting your order so you have a copy for your records. After filling with compund solution, implantation can be performed in just minutes. Empty reservoir within the core of the pump is filled with the drug or hormone solution to be delivered and is surrounded by salt chamber with impermeable layer between them it is an implantable osmotic pumps for laboratory animal the pump are used to deliver homogenous solution or suspension continuously at a. This video describes the subcutaneous and intraperitoneal. Watch this video to learn about the iprecio smp200 pump technology and applications. Alzet osmotic pumps are miniature, implantable pumps for research in mice, rats, and other laboratory animals. Pumps implanted in animal body for continuous infusions from 1 day to 6 weeks. Download our whitepaper, advancing cancer treatments with alzet.
Alzet customer service will contact you by the next business day to confirm your order and to supply pricing information. If so, share your ppt presentation slides online with. Osmotic pumps release drug at a rate that is independent of the ph and hydrodynamics of the dissolution medium. After necropsy, the length of the femora and tibiae were analyzed. This video demonstrates subcutaneous and intraperitoneal implantations, intravenous infusion via the external jugular vein, localized administration into the central nervous system. Osmotic pumps can be used for systemic administration. Common routes of administration requiring use of a catheter. Osmoticcontrolled release oral delivery system wikipedia.
Btw, does anyone of you know other manufacturer of osmotic pumps than alzet. Watch this short video for an overview of the alzet technology, benefits and applications. Implantable infusion pumps for continuous administration of test agents to unrestrained laboratory animals. Microosmotic pumps for continuous release of the tyrosine. Louis, mo and is dissolved in phosphate buffered saline. Osmotic drug delivery system as a part of modified release. Alzet osmotic pumps are miniature, implantable pumps used for research in mice. Pumps are sold empty, and are easily filled with your test agent via syringe.
1447 1016 345 506 764 1280 1549 850 864 328 1314 479 292 683 1106 1317 1337 94 1104 22 620 532 1301 754 264 1470 1404 937 570 383 577