Osmotic drug delivery systems typically consist of a drug core containing osmogen that is coated with a semipermeable membrane. In general, three different operating principles of osmotic pumps having distinct advantages and. If you require further information on these osmotic pumps, feel free to contact us at the following. Subcutaneous angiotensin ii infusion using osmotic pumps. This video describes the subcutaneous and intraperitoneal. Alzet pumps deliver by the process of osmotic displacement. Preparation of alzet osmotic pumps for subcutaneous implantation reagentssupplies 1. Common routes of administration requiring use of a catheter.
This video shows the parts of the pump and describes how the pump operates to enable continuous delivery alzet resource videos osmotic pump mechanism on vimeo. Convenient, reliable, and costeffective alternative to chronic injections. Louis, mo and is dissolved in phosphate buffered saline. Osmotic pumps are one of the systems for controlled drug delivery. Preparation and implantation alzet osmotic pumps sop9 osmotic pumps manufactured by alza corporation palo alto, ca are designed for constant rate delivery of test solutions over a. Durect corporation alzet osmotic no 1004 pump alzet osmotic no 1004 pump. Download free osmosis prime videos 2018 875 videos go beyond medical lectures. If so, share your ppt presentation slides online with. These minipumps provide researchers with a method for controlled and continuous agent delivery in vivo. Download our whitepaper, advancing cancer treatments with alzet. Alzet osmotic pumps surgical implantation techniques alza corp.
This video demonstrates subcutaneous and intraperitoneal implantations, intravenous infusion via the external jugular vein, localized administration into the central nervous system. Isoproterenol 17 mgkgday was administered to mice using alzet osmotic minipumps durect corp, cupertino, ca. Alzet surgical implantation procedures video youtube. This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents. Comprehensive coverage of pathology, physiology, pharmacology, and clinical reasoning videos you wont find anywhere else. By varying the concentration of the active agent in the dispersion, the amounts delivered can be varied at a constant temperature amkraut et al. Only the magnitude and the duration of delivery change. Watch this short video for an overview of the alzet technology, benefits and applications. A filling needle is included in the box with osmotic pumps. An infusion pump infuses fluids, medication or nutrients into a patients circulatory system. Video article demonstrating icv delivery to the mouse cns. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports.
Miniosmotic pumps alzet 2001, 2004, 2006 or microosmotic pumps alzet 1004. Osmotic pumps are miniature infusion pumps for the continuous dosing of laboratory animals. Microosmotic pumps for continuous release of the tyrosine kinase inhibitor bosutinib in juvenile rats and its impact on bone growth. Specify the model, order number and quantity of pumps you require. Introduction osmosis refers to the process of movement of solvent from lower concentration of solute towards higher concentration of solute across a semi permeable membrane till the equilibrium achieved. Lab animals this video shows lab animals implanted with alzet pumps, and describes how alzet pumps improve animal welfare by reducing the stress caused by repetitive injections and frequent animal handling.
The automatic operation and small size of alzet pumps make them an ideal infusion system for chronic dosing studies in nude and scid mouse models. Prior to inserting the minipumps, mice will be anesthetized using avertin 0. This video describes the subcutaneous and intraperitoneal implantation procedures. Implantable infusion pumps for continuous administration of test agents to unrestrained laboratory animals. Watch the above overview video to learn more about the technology, benefits, and. Osmoticcontrolled release oral delivery system wikipedia. Selfpowered pumps are then implanted either subcutaneously or intraperitoneally. Pumps are sold empty, and are easily filled with your test agent via syringe. Whatever i found, it was either alzet or a reseller of alzet. Microosmotic pumps for continuous release of the tyrosine. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic. An osmotic pump comprises a first chamber 8 comprising an osmotically active substance 18, a second chamber 15 arranged to be filled with a solvent 17, and a semipermeable barrier 14 separating the first chamber 8 from the second chamber 15. Alzet surgical implantation procedures video on vimeo.
As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the. Highmolecularweight polyox is used to formulate the push layer, whereas the pull layer. Osmotic pumps can be used for systemic administration. Alzet resource videos osmotic pump mechanism on vimeo. Alzet osmotic pumps have been a part of successful research for over 40 years. A grasping tool device for delicately grasping tissue comprising. Alzet osmotic pumps implantable infusion pumps for. Maximize therapeutic efficacy and reduce adverse effects. Download article pdf download research materials list.
Empty reservoir within the core of the pump is filled with the drug or hormone solution to be delivered and is surrounded by salt chamber with impermeable layer between them it is an implantable osmotic pumps for laboratory animal the pump are used to deliver homogenous solution or suspension continuously at a. It is generally used intravenously, although subcutaneous, arterial and epidural infusions are occasionally used infusion pumps can administer fluids in ways that would be impractically expensive or unreliable if performed manually by nursing staff. Osmotic drug delivery system as a part of modified release. In addition, durect has a video available on cd or for download that demonstrates surgical techniques and special applications for the use of alzet osmotic pumps. There are 12 models of alzet osmotic pumps in 3 physical sizes, and a variety of release rates and durations. Osmotic micropumps for drug delivery sciencedirect. Ppt electro osmotic pumps powerpoint presentation free.
After necropsy, the length of the femora and tibiae were analyzed. Implantable infusion pumps insights for your next animal dosing study. The osmoticcontrolled release oral delivery system oros is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semipermeable outer membrane and one or more small laser drilled holes in it. These minipumps deliver drugs, hormones, and other test agents at continuous and controlled rates, for durations ranging from one day to six weeks, without the need for external connections or frequent handling. Alzet pumps can also be used for targeted delivery, where the effects of a drug or test agent are localized in a particular tissue or organ, by means of a catheter. Electro osmotic pumps is the property of its rightful owner. Individual lots of pumps may vary from this target within limits. You may wish to print this form before submitting your order so you have a copy for your records. Alzet customer service will contact you by the next business day to confirm your order and to supply pricing information. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery of experimental agents.
These minipumps deliver drugs, hormones, and other test agents at continuous and. Continuous delivery ensures constant compound levels in plasma or tissues for. Osmotic pumps release drug at a rate that is independent of the ph and hydrodynamics of the dissolution medium. Osmotic pump delivery systems are typically produced on a bilayer tablet press and subsequently coated with a semipermeable membrane. After filling with compund solution, implantation can be performed in just minutes. Pumps implanted in animal body for continuous infusions from 1 day to 6 weeks. Watch this video to learn about the iprecio smp200 pump technology and applications. Video articles in jove about mini osmotic pump include spectral confocal imaging of fluorescently tagged nicotinic receptors in knockin mice with chronic nicotine administration, construction and implantation of a microinfusion system for sustained delivery of neuroactive agents. Btw, does anyone of you know other manufacturer of osmotic pumps than alzet.
This video describes proper filling of the alzet pump and and surgical techniques for implantation in rats and mice including subcutaneous and interperitoneal implantation, and the use of a catheter for intravenous, intrathecal, intragastric, and cranialcerebral infusion. Alzet osmotic pumps have been used extensively in immunodeficient mice since 1980 and over 300 publications are available as evidence of their research value in these species. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. This video article jove describes a method for targeted administration of drugs to the central nervous system by either continuous delivery using alzet osmotic pumps or performing bolus injections into the right lateral ventricle of mice. This video describes proper filling of the alzet pump and and surgical techniques for implantation in rats and mice including subcutaneous and interperitoneal. The semipermeable barrier 14 is impermeable for the osmotic active substance and permeable for the solvent 17. This coating has one or more delivery ports through which a solution or suspension of the drug is released over time. Principles of the design and operation of generic osmotic pumps. Free access to all jove education videos until june 15. Durect corporation 2006 alzet osmotic pump 42 day 2006. Alzet osmotic pumps are miniature infusion systems that deliver test agents at. Department of pharmaceutics, institute of pharmacy, nirma university, sarkhejgandhinagar highway, ahmadabad 382 481, gujarat, india. Alzet osmotic pumps are miniature, implantable pumps used for research in mice.
Durect corporation 2006 alzet osmotic pump 42 day 2006 alzet osmotic pump 42 day. These selfpowered pumps offer a convenient and efficient method for longterm dosing of mice and rats. Versatile and highly swellable polyox watersoluble resins help with the production of osmotic pump technologies. Appendix 11 video tapes vhs available through veterinary resources current 1999 1. Durect corporation alzet osmotic no 1004 pump alzet. Alzet osmotic pumps surgical implantation techniques. Alzet osmotic infusion pumps model 2002 pack of 10 pumps. Catheter tubing catheters premade needles port plugs tubing connectors stopcocks stylets injection ports osmotic pumps. This 20 minute video describes the alzet pump mechanism, and the advantages of continuous infusion over frequent.
Alzet pumps are miniature delivery systems designed to provide constant, accurate administration of test agents. These infusion pumps continuously deliver drugs, hormones, and other test agents at controlled rates from one day to six weeks without the need for external connec. Alzet pumps have been used to target delivery to a wide variety of sites including the spinal cord, spleen, liver, organ or tissue transplants, and wound. Though these solvents exhibit the potential to solubilize several poorly soluble compounds, the solubilized compounds are prone to crystallization up on contact. Durect manufactures and sells alzet osmotic pumps and accessories on a worldwide basis. The historical development of osmotic systems includes development of the rosenelson pump, the higuchileeper pumps, the alzet and osmet systems, the elementary osmotic pump, and the pushpull. Alzet osmotic pumps have been a part of successful research for more than 40 years. Osmotic micropumps for drug delivery are applied to a broad range of different applications addressing multiple routes of administration. Articular cavity, blood vessels, bone, brain solid tissue, brain ventricles, ear, eye, muscle, nerves, spinal cord, stomach, and tumors.
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